In dieser Übersicht finden Sie eine Auswahl von kPNI-relevanten Publikationen und wissenschaftlichen Veröffentlichungen aus unserem Netzwerk.

Please find some cpni relevant publications and publications from researchers out of our network below.


An evolutionary perspective on (chronic) disease
(Ruiz-Nunez, Begona)

Intermittent living; the use of ancient challenges as a vaccine against the deleterious effects of modern life – A hypothesis
(Pruimboom, Leo; Muskiet, Frits A.J).

Characterization in humans of in vitro leucocyte maximal telomerase activity capacity and association with stress
(de Punder, Karin; Heim Christine; Przesdzing, Ingo; Wadhwa, Pathik D.; Entringer, Sonja)

An evolutionary perspective on nutrition and social decision making
(Raison, Charles L.; A. Raichlen, David)


Characterization of in vitro leukocyte maximal telomerase activity capacity (mTAC) in humans: Association with chronic stress exposure and stress-reactivity
(de Punder, Karin; Heim Christine; Przesdzing, Ingo; Wadhwa, Pathik D.; Entringer, Sonja)

The sedentary (r)evolution: Have we lost our metabolic flexibility?
(Freese, Jens; Rainer Johannes Klement; Ruiz-Núñez, Begoña; Schwarz, Sebastian; Lötzerich, Helmut).


Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial
(Buigues, Cristina; Fernández-Garrido, Julio; Pruimboom, Leo; Hoogland, Aldert J.; Navarro-Martínez, Rut; Martínez-Martínez, Mary; Verdejo, Yolanda; Mascarós, Mari Carmen; Peris, Carlos; Cauli, Omar)

Back to the Future. Metabolic Effects of a 4-Day Outdoor Trip Under Simulated Paleolithic Conditions – New Insights from The Eifel Study
(Freese, Jens; Pardi, Daniel J.; Ruiz-Núñez, Begoña; Schwarz, Sebastian; Heynck, Regula; Renner, Robert; Zimmer, Philipp; and Lötzerich, Helmut).

Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The “Study of Origin”
(Pruimboom, Leo; Ruiz-Nunez, Begona; Raison, Charles L.; Muskiet, Frits A.J.; Freese Jens)

Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial
(Cristina Buigues, Julio Fernández-Garrido, Leo Pruimboom, Aldert J. Hoogland, Rut Navarro-Martínez, Mary Martínez-Martínez, Yolanda Verdejo, Mari Carmen Mascarós, Carlos Peris and Omar Cauli)

Intermittent drinking, oxytocin and human health
(Pruimboom, Leo; Reheis, Daniel)

To Restore Health, “Do we Have to Go Back to the Future?” The Impact of a 4-Day Paleolithic Lifestyle Change on Human Metabolism – a Pilot Study.(Freese, Jens; Ruiz-Núñez, Begoña; Heynck, Regula; Schwarz, Sebastian; Pruimboom, Leo; Renner, Robert; and Lötzerich, Helmut)


The opioid effects of gluten exorphins: asymptomatic celiac disease
(Leo Pruimboom, Karin de Punder; 2015)

Physical Activity Protects the Human Brain against Metabolic Stress Induced by a Postprandial and Chronic Inflammation
(Pruimboom, Raison, Muskiet; 2015)

Stress Induces Endotoxemia and Low-Grade Inflammation by Increasing Barrier Permeability
(Karin de Punder, Leo Pruimboom; 2015)


Inflammatory depression: a trifecta of trouble. (Raison, C. L., J Clin Psychiatry, 75(6), 663-664. doi: 10.4088/JCP.14ac09217)

Lactase persistence and augmented salivary alpha-amylase gene copy numbers might have been selected by the combined toxic effects of gluten and (food born) pathogens. (Pruimboom, L., Fox, T., & Muskiet, F. A.,Med Hypotheses, 82(3), 326-334. doi: 10.1016/j.mehy.2013.12.020)


Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context. (Ruiz-Nunez, B., Pruimboom, L., Dijck-Brouwer, D. A., & Muskiet, F. A., J Nutr Biochem, 24(7), 1183-1201. doi: 10.1016/j.jnutbio.2013.02.009)

The dietary intake of wheat and other cereal grains and their role in inflammation. (de Punder, K., & Pruimboom, L., Nutrients, 5(3), 771-787. doi: 10.3390/nu5030771)