In dieser Übersicht finden Sie eine Auswahl von kPNI-relevanten Publikationen und wissenschaftlichen Veröffentlichungen aus unserem Netzwerk.

Please find some cpni relevant publications and publications from researchers out of our network below.


Effects of the menstrual cycle on the performance of female football players. A systematic review
(Hamed-Hamed D, González-Muñoz A, Cuevas-Cervera M, Perez-Montilla JJ, Aguilar-Nuñez D, Aguilar-García M, Pruimboom L, Navarro-Ledesma S.)

A new perspective of frozen shoulder pathology; the interplay between the brain and the immune system
(Santiago Navarro-Ledesma, Dina Hamed-Hamed, Leo Pruimboom)

The effectiveness of oral bovine lactoferrin compared to iron supplementation in patients with a low hemoglobin profile: A systematic review and meta-analysis of randomized clinical trials
(Maria-Dolores Christofi, Konstantinos Giannakou, Meropi Mpouzika, Anastasios Merkouris, Maria Vergoulidou – Stylianide & Andreas Charalambous)


Maximal telomerase activity capacity (mTAC) underlies the link between the cortisol response to stress and telomere length
(Karin de Punder, Christine Heim, Dries S. Martens, Pathik D. Wadhwa, Sonja Entringer)

Mitochondria: It is all about energy
(Amaloha CasanovaAnne WeversSantiago Navarro-LedesmaLeo Pruimboom)

Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review
(Ana González-MuñozMaría Cuevas-CerveraJosé Javier Pérez-MontillaDaniel Aguilar-NúñezDina Hamed-HamedMaría Aguilar-GarcíaLeo PruimboomSantiago Navarro-Ledesma)

Omega-3 fatty acids in heart disease-why accurately measured levels matter
(C von SchackyR S KuipersH PijlF A J MuskietD E Grobbee)

Editorial: Biopsychosocial complexity research
(Christian SchubertWilliam SulisAlejandro De La Torre-LuqueGünter K Schiepek)


Obesity and Leptin Resistance in the Regulation of the Type I Interferon Early Response and the Increased Risk for Severe COVID-19
(Frits A J MuskietPedro Carrera-BastosLeo PruimboomAlejandro LuciaDavid Furman)

Circadian Variation of Blood Pressure in Patients with Chronic Musculoskeletal Pain: A Cross-Sectional Study
(Santiago Navarro-LedesmaAna Gonzalez-MuñozMaria Carmen García RíosDaniel de la SernaLeo Pruimboom)

Patellar and Achilles Tendon Thickness Differences among Athletes with Different Numbers of Meals per Day: A Cross-Sectional Study
(Santiago Navarro-LedesmaGabriel Gijon-NogueronInmaculada Reina-MartínAna Belen Ortega-AvilaLeo Pruimboom)

Do Psychological Factors Influence the Elastic Properties of Soft Tissue in Subjects with Fibromyalgia? A Cross-Sectional Observational Study
(Santiago Navarro-LedesmaMaría Aguilar-GarcíaAna González-MuñozLeo PruimboomMaría Encarnación Aguilar-Ferrándiz)

The Relationship between Daily Physical Activity, Psychological Factors, and Vegetative Symptoms in Women with Fibromyalgia: A Cross-Sectional Observational Study
(Santiago Navarro-LedesmaLeo PruimboomEnrique LluchLirios DueñasSilvia Mena-Del HornoAna Gonzalez-Muñoz)

Thyroidal and Extrathyroidal Requirements for Iodine and Selenium: A Combined Evolutionary and (Patho)Physiological Approach
(D A Janneke Dijck-BrouwerFrits A J MuskietRichard H VerheesenGertjan SchaafsmaAnne SchaafsmaJan M W Geurts)


A Comprehensive View of Frozen Shoulder: A Mystery Syndrome.
(de la Serna D, Navarro-Ledesma S, Alayón F, López E, Leo Pruimboom)


Epigenetic regulation of macrophages: from homeostasis maintenance to host defense
(Siyuan ChenJing YangYuquan WeiXiawei Wei)

Methylation Pathways and SARS-CoV-2 Lung Infiltration and Cell Membrane-Virus Fusion Are Both Subject to Epigenetics
(Leo Pruimboom)

SARS-CoV 2; Possible alternative virus receptors and pathophysiological determinants
(Leo Pruimboom)

Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial
(Francisco M Martínez-ArnauRosa Fonfría-VivasCristina BuiguesYolanda CastilloPilar MolinaAldert J HooglandFemke van DoesburgLeo PruimboomJulio Fernández-GarridoOmar Cauli)


An evolutionary perspective on (chronic) disease
(Ruiz-Nunez, Begona)

Intermittent living; the use of ancient challenges as a vaccine against the deleterious effects of modern life – A hypothesis
(Pruimboom, Leo; Muskiet, Frits A.J).

Characterization in humans of in vitro leucocyte maximal telomerase activity capacity and association with stress
(de Punder, Karin; Heim Christine; Przesdzing, Ingo; Wadhwa, Pathik D.; Entringer, Sonja)

An evolutionary perspective on nutrition and social decision making
(Raison, Charles L.; A. Raichlen, David)


Characterization of in vitro leukocyte maximal telomerase activity capacity (mTAC) in humans: Association with chronic stress exposure and stress-reactivity
(de Punder, Karin; Heim Christine; Przesdzing, Ingo; Wadhwa, Pathik D.; Entringer, Sonja)

The sedentary (r)evolution: Have we lost our metabolic flexibility?
(Freese, Jens; Rainer Johannes Klement; Ruiz-Núñez, Begoña; Schwarz, Sebastian; Lötzerich, Helmut).


Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial
(Buigues, Cristina; Fernández-Garrido, Julio; Pruimboom, Leo; Hoogland, Aldert J.; Navarro-Martínez, Rut; Martínez-Martínez, Mary; Verdejo, Yolanda; Mascarós, Mari Carmen; Peris, Carlos; Cauli, Omar)

Back to the Future. Metabolic Effects of a 4-Day Outdoor Trip Under Simulated Paleolithic Conditions – New Insights from The Eifel Study
(Freese, Jens; Pardi, Daniel J.; Ruiz-Núñez, Begoña; Schwarz, Sebastian; Heynck, Regula; Renner, Robert; Zimmer, Philipp; and Lötzerich, Helmut).

Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The “Study of Origin”
(Pruimboom, Leo; Ruiz-Nunez, Begona; Raison, Charles L.; Muskiet, Frits A.J.; Freese Jens)

Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial
(Cristina Buigues, Julio Fernández-Garrido, Leo Pruimboom, Aldert J. Hoogland, Rut Navarro-Martínez, Mary Martínez-Martínez, Yolanda Verdejo, Mari Carmen Mascarós, Carlos Peris and Omar Cauli)

Intermittent drinking, oxytocin and human health
(Pruimboom, Leo; Reheis, Daniel)

To Restore Health, “Do we Have to Go Back to the Future?” The Impact of a 4-Day Paleolithic Lifestyle Change on Human Metabolism – a Pilot Study.(Freese, Jens; Ruiz-Núñez, Begoña; Heynck, Regula; Schwarz, Sebastian; Pruimboom, Leo; Renner, Robert; and Lötzerich, Helmut)


Impact of Early-Life Exposures on Immune Maturation and Susceptibility to Disease
(Eva S GollwitzerBenjamin J Marsland)

The opioid effects of gluten exorphins: asymptomatic celiac disease
(Leo Pruimboom, Karin de Punder)

Physical Activity Protects the Human Brain against Metabolic Stress Induced by a Postprandial and Chronic Inflammation
(Pruimboom, Raison, Muskiet)

Stress Induces Endotoxemia and Low-Grade Inflammation by Increasing Barrier Permeability
(Karin de Punder, Leo Pruimboom)


Inflammatory depression: a trifecta of trouble. (Raison, C. L., J Clin Psychiatry, 75(6), 663-664. doi: 10.4088/JCP.14ac09217)

Lactase persistence and augmented salivary alpha-amylase gene copy numbers might have been selected by the combined toxic effects of gluten and (food born) pathogens. (Pruimboom, L., Fox, T., & Muskiet, F. A.,Med Hypotheses, 82(3), 326-334. doi: 10.1016/j.mehy.2013.12.020)

Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected program used in chronic inflammatory diseases (Straub, RH. Arthritis Res Ther. 2014 Nov 13;16 Suppl 2(Suppl 2):S4.  doi: 10.1186/ar4688.)


Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context. (Ruiz-Nunez, B., Pruimboom, L., Dijck-Brouwer, D. A., & Muskiet, F. A., J Nutr Biochem, 24(7), 1183-1201. doi: 10.1016/j.jnutbio.2013.02.009)

The dietary intake of wheat and other cereal grains and their role in inflammation. (de Punder, K., & Pruimboom, L., Nutrients, 5(3), 771-787. doi: 10.3390/nu5030771)


Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering
(Margarethe M Bosma-den BoerMarie-Louise van WettenLeo Pruimboom)


Chronic pain: a non-use disease
(L PruimboomAC van Dam)


Cytokines sing the blues: inflammation and the pathogenesis of depression
(CL Raison, L Capuron, AH Miller)



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